Original Research Article
Year: 2019 | Month: October | Volume: 6 | Issue: 10 | Pages: 9-14
Liver Enzymes as Predictors of Risk of Diabetes among First Degree Relatives of Type 2 Diabetes Patients
Dr Maithri CM1, Tejaswini2, Dr Kruthi BN2, Manoj P3, Pooja S2
1Assistant Professor, Mandya Institute of Medical Sciences, Mandya
2Tutor, Mandya Institute of Medical Sciences, Mandya
3Final year MBBS Student, Mandya Institute of Medical Sciences Mandya
Corresponding Author: Dr Kruthi BN
ABSTRACT
Background and objectives: Increased concentration of liver enzymes has been implicated in the pathogenesis of type 2 diabetes. The aim of our study was to determine the association between liver enzymes and risk of type 2 diabetes among first degree relatives (FDR) of type 2 diabetes patients.
Methodology: 150 non-diabetic FDR of type 2 diabetic patients were enrolled. Detailed history of participants was taken, followed by anthropometric measurements and estimation of biochemical parameters was done. According to American Diabetic Association criteria, the participants were classified into euglycemic, prediabetic and diabetic groups based on their fasting blood glucose value. The associations between liver enzymes and risk of diabetes were analyzed using correlation and receiver operating characteristic curve analysis (ROC).
Results: In the present study 150 FDR’s of type 2 diabetic patients were grouped into euglycemic (54), pre diabetic (47) and diabetic (49). Statistically significant positive correlation between liver enzymes Gamma glutamyl transferase (GGT) Vs Aspartate Transaminase (AST) (r=0.394), GGT Vs Alanine transaminase (ALT) (r=0.466) & AST Vs ALT (r=0.630) was observed. ROC analysis of liver enzymes with fasting blood glucose showed the cut-off predictive values for type 2 diabetes were >29U/L, >21U/L and >16U/L for GGT, AST and ALT respectively. Area under the curve (AUC) value for GGT was more as compared to AST and ALT.
Conclusion: The present study showed that increased levels of liver enzymes within its normal range can predict risk of development of diabetes. Among the liver enzymes GGT emerged as a biomarker to assess the risk of diabetes among FDR of type 2 diabetic patients.
Key words: Type 2 diabetes, First Degree Relatives, Gamma Glutamyl Transferase, Aspartate Transaminase, Alanine transaminase.
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