Original Research Article
Year: 2019 | Month: October | Volume: 6 | Issue: 10 | Pages: 132-136
Seroprevalence of Dengue NS1 Antigen in a Tertiary Care Hospital, Jamnagar
Dr. Akansha Goyal1, Dr. Binita Aring2, Dr. Hiral Gadhavi3, Dr. Summaiya Mullan4, Kamaxi Trivedi5
1Second year Resident, 2Associate Professor, 3Assistant Professor, 4Professor& Head, 5Lab Technician,
Department of Microbiology, Shri M.P.Shah Govt Medical College, Jamnagar
Corresponding Author: Dr. Akansha Goyal
ABSTRACT
Background: Dengue is one of the most serious mosquito-borne viral infections affecting tropical and subtropical countries in the world. Since there is no immune prophylactic or specific antiviral therapy available, timely and rapid diagnosis plays a vital role in patient management and implementation of control measures.
Study design: Cross sectional Study was conducted from April-2018 to March-2019.Total 1786 blood samples of patient suspected of Dengue NS-1 Antigen by ELISA method.
Objectives: To find out sero-prevalence of dengue NS-1 in and around Jamnagar by presence of virus specific NS-1 antigen from serum samples taken from patients with clinical features suggestive of Dengue.
Material and methods: Patients attending outpatient department or admitted in a tertiary care hospital, Jamnagar with fever, headache, body ache, myalgia or signs and symptoms suggestive of Dengue were included in the study. Blood samples were screened for dengue NS-1 antigen by ELISA
Result: Total 1786 samples were tested for dengue NS1 antigen, out of these 280 samples (16%) were tested positive for NS1.
Out of 280 positive samples, 168 samples (60%) were of 3-4 days of illness. Dengue fever shows seasonal peak in the month of October when 95 out of 280 (34%) samples were positive.
Conclusion: NS1 antigen detection has potential value for screening patient samples during the early acute phase. It is rapid, easy to perform & interpret and has an extended shelf life. We conclude that dengue NS1 antigen detection is an effective tool for early diagnosis of dengue infection.
Key words: Dengue, NS1 Antigen
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