Research Paper
Year: 2019 | Month: October | Volume: 6 | Issue: 10 | Pages: 275-280
The Effect of Given Ferrous Sulfate, Ferrous Sulfate Plus Vitamin C and Ferrous Iron with Glucose Levels and Blood Hemoglobins in Pregnant Rats
Endang Sari1, Andani Eka Putra2, Rauza Sukma Rita3
1Master of Midwifery Program, Faculty of Medicine, Universitas Andalas, Padang City, Indonesia
2Department of Microbiology, Faculty of Medicine, Universitas Andalas, Padang City, Indonesia
3Department of Biochemistry, Faculty of Medicine, Universitas Andalas, Padang City, Indonesia
Corresponding Author: Endang Sari
ABSTRACT
Background: Iron Nutrition Anemia is one of the nutritional problems in Indonesia that must get serious attention. One of the prevention of anemia is by giving iron, iron is more easily absorbed with vitamin C in the intestine compared to only drinking of iron. The aim of the study was to know effect of given ferrous sulfate, ferrous sulfate plus vitamin C and ferrous iron with glucose levels and blood hemoglobins in pregnant rats.
Methods: The study was conducted using experimental study with pre and post test control group design. The sample in this study were female white rat (Rattus novergicus), aged 2-3 months and body weight 200-250 grams, consisted of four groups (t1 = control group, t2 = giving Fe group, t3 = giving Fe + Vit C, t4 = giving elemental Fe), sample size 28 rats and 7 rats in each group. Giving Ferro Sulfate and Vitamin C done through a sonde in female Rattus Novergicus rats during pregnancy from the first day of pregnancy until the gestational age reaches 18th days. In female rat said to experience pregnancy with a gestational period ranging from 20-22 days. Giving doses in each treatment group were 200 mg ferrous sulfate, 100 mg vitamin C and 60 mg ferrous iron. Hypothesis test used one-way anova. A two-tailed P-value of <0.05 was considered statistically significant.
Results: Blood glucose levels before and after treatment in the control group and the group giving ferrous sulfate plus vitamin C had a significant decrease in blood glucose levels while blood glucose levels before and after treatment in the ferrous sulfate group and the ferrous iron administration group had a significant increase in glucose blood levels (p <0.05). Blood glucose levels in pregnant rats after being given ferrous sulfate, ferous sulfate plus vitamin c, and ferrous iron which has the lowest blood glucose levels were the ferous sulfate plus vitamin c group, and those that have the highest blood glucose levels were in the ferrous iron group. Comparison of blood glucose levels in each variable can be seen only the control group that had a significant relationship to the group giving ferrous sulfate (p <0.05). Blood hemoglobin levels before and after treatment in the control group had a significant decrease whereas in the group giving ferrous sulfate, the group giving ferrous sulfate plus vitamin C and ferrous iron experienced a significant increase in blood hemoglobin levels (p <0.05). Blood hemoglobin levels in pregnant rats after being given ferrous sulfate, ferrous sulfate plus vitamin c, and ferrous iron which have the highest hemoglobin levels were in the ferrous sulfate group. Comparison of blood hemoglobin levels in each variable can be seen only the control group that had a significant relationship to the group giving ferrous sulfate, ferrous sulfate plus vitamin C and ferrous iron.
Conclusion: This analysis confirmed iron can increase blood glucose for that consumption of iron supplements without any indication wit low hemoglobin is not recommended.
Key words: Iron, Blood Glucose, Hemoglobin, Vitamin C
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