Original Research Article
Year: 2019 | Month: November | Volume: 6 | Issue: 11 | Pages: 19-25
Study on Essential Hypertension and Renal Impairment: A Descriptive Cross-Sectional Study
Dr Kruthi BN1, Dr Sahana KR2
1Tutor, Mandya Institute of Medical Sciences, Mandya
2Assistant Professor, Bowring & Lady Curzon Medical College Research Centre, Bangalore.
Corresponding Author: Dr Sahana KR
ABSTRACT
Background and objectives: Hypertension (HTN) is one of the commonest non-communicable diseases and it is the major public health problem in our country. The kidney is a main target of organ damage in uncontrolled chronic HTN. The aim of our study was to determine the correlation between the HTN, serum creatinine, MAU (Microalbuminuria) and eGFR (Estimated Glomerular Filtration Rate) and gender differences in renal function parameters.
Methodology:112 essential hypertensive subjects between the age group of 30-60 years were included in the present study. Physical measurements, Blood pressure and biochemical investigations were done in the study subjects who were consented to be part of the present study.
Results: Out of 112 hypertensive subjects 70 (62.5%) had MAU, 1 (0.9%) had increased serum creatinine and 57 (50.89%) had lower eGFR. The mean values of MAU, serum creatinine were lower among female hypertensives as compared to male hypertensives. However mean value of eGFR was higher among male hypertensives as compared to female hypertensives. From the Receiver Operative Characteristic (ROC) curve it was found that, area under the curve (AUC) for MAU -0.796, eGFR – 0.617 and serum creatinine - 0.456 with stages of HTN.
Conclusion: In our study, males had higher percentage of MAU and decreased eGFR was common among female hypertensives.AUC for MAU was more as compared to other two parameters and hence in our study MAU is a better parameter to assess the renal impairment with stages of HTN. Therefore early screening of hypertensive patients for MAU might reduce the risk of chronic kidney diseases.
Key words: Hypertension; Serum creatinine; Microalbuminuria; eGFR and renal impairment.
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