Original Research Article
Year: 2019 | Month: November | Volume: 6 | Issue: 11 | Pages: 249-253
Non-Invasively Measured Augmentation Index in Relation To Severity of Coronary Artery Disease Evaluated by SYNTAX Score in Essential Hypertensive Patients with and Without Metabolic Syndrome
Biju Govind1, Anil Kumar Naralasetty1, John Satish Rudrapogu1, Sadhna Sharma2
1Department of Cardiology, 2Department of Medicine,
NRI Medical College and Hospital, Chinakakani, Guntur District, Andhra Pradesh - 522503, India
Corresponding Author: Biju Govind
ABSTRACT
Background: Cardiovascular risk is twice as high in patients with metabolic syndrome as compared to those without the syndrome. This prospective study aimed to correlate non-invasively measured augmentation index with severity of coronary artery disease evaluated by the SYNTAX score on coronary angiography in hypertensive patients with and without metabolic syndrome.
Methods: A prospective, cross-sectional, hospital-based study was conducted during December 2015 and December 2016 among 100 patients aged 18–69.Peripheral blood pressure was measured with a sphygmomanometer whereas central aortic blood pressure was measured using the Pulse Cor machine. All patients received appropriate medical treatment which included beta-blockers, angiotensin-converting-enzyme inhibitors, angiotensin II receptor blockers, or calcium channel blockers.
Results: A total of 100 patients participated in the study. Majority, 38 (38.0%) patients were between 60–69 years old. Males contributed 71 (71.0%) of the study population. Mean augmentation index was highest in non-smokers with metabolic syndrome (95.4±72.4), whereas mean SYNTAX score was highest in smokers with metabolic syndrome (14.8±7.0). Similarly, mean augmentation index was highest in the BB/BB ARB group (97.9±55.6), whereas mean SYNTAX scores was highest in the ARB/ ARB DIURETIC group (15.0±5.9).
Conclusion: In our study, augmentation index showed a weak positive correlation with severity of coronary artery disease. These findings may be justified by wide use of atenolol as the major antihypertensive drug used in our study.
Key words: augmentation index, coronary artery disease, central aortic blood pressure, hypertension, metabolic syndrome, SYNTAX score
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