Original Research Article
Year: 2019 | Month: November | Volume: 6 | Issue: 11 | Pages: 37-43
Comparative Evaluation of Antioxidant Activity of Methanolic Extract of Saraca asoca and its Commonly Used Substitute Plants
Suhail PT
Assistant Professor, Al Shifa College of Pharmacy, Kizhattur, Poonthavanam PO, Perinthalmanna, Malappuram, Kerala, 679325
ABSTRACT
Objective-This study was carried out to compare antioxidant activity of methanolic extract of Saraca asoca and its commonly used substitute plants Kingiodendron pinnatum, and Cynometra travancorica.
Method- Chopped bark of each plant where blundered and extracted with methanol, the antioxidant activity were evaluated using Swiss Albino mice.
Results- The antioxidant enzymes and glutathione in blood, serum and tissue was evaluated. Enzyme activity was found to be significantly increased in extracts treated with 200 and 400 mg/kg. The percentage increase of catalase enzyme in each extract was, Saraca asoca (19.97 and 33.17%), Kingiodendron pinnatum (10.09 and 36.87%)and Cynometra travancorica (15.92 and 49.19%) respectively. The activity of superoxide dismutase was 16.89 and 31.33%, 24.43 and 39.05%, 27.91 and 48.58%. The percentage increase of glutathione was found to be 25.98 and 51.69%, 19.21 and 43.76%, 9.75 and 56.36% respectively.
Conclusion- The data obtained from the study indicate that the extract prepared with Cynometra travancorica and Kingiodendron pinnatum shown significant increase of antioxidant enzymes. So Saraca asoca can be substituted with these two plants.
Key words: Saraca asoca, Kingiodendron pinnatum, Cynometra travancorica, antioxidant enzymes.
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