Original Research Article
Year: 2019 | Month: November | Volume: 6 | Issue: 11 | Pages: 472-477
Effect of Vitamin D Supplementation on Calcium Homeostasis in Psoriasis
Dr Ekta Debnath1, Dr Vijay Shankar2, Dr Parijat Gogoi3, Dr Pinaki Ranjan Debnath4
1Professor, 3Associate Professor,
Department of Biochemistry, Lady Hardinge Medical College, New Delhi-01
2Ex-Professor, Department of Biochemistry, PGIMER Rohtak
4Associate Professor, Department of Paediatric Surgery, ABVIMS &Dr RML Hospital, New Delhi-01
Corresponding Author: Dr Parijat Gogoi
ABSTRACT
Vitamin D is traditionally known to play the biological function of maintaining normal blood levels of calcium and phosphorus in our body and thereby is necessary for mineral homeostasis and proper formation of bone. Recently a role of Vit D in the pathogenesis of different skin diseases, including psoriasis, has been reported. The present study was planned to evaluate the therapeutic usefulness of oral vitamin D supplementation in psoriasisand its effect on various biochemical parameters related to calcium homeostasis and kidney functions in patients of psoriasis. The results show that vit D (cholecalciferol), has a beneficial role on psoriatic lesions with improvement in PASI scoring when compared to patients on topical treatment and that a daily low dose of vit D, does not significantly affect the calcium metabolism, renal function or hepatic function, and hence may prove to be an efficacious treatment for psoriasis.
Key words: Vitamin D (vitD), Psoriasis Area Severity Index (PASI), Albumin Corrected Calcium (ACC)
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