Case Report
Year: 2019 | Month: November | Volume: 6 | Issue: 11 | Pages: 533-534
A Case Report on Ceftriaxone Induced Hypersensitivity Reaction
Anjalimol P.T1, Priscilla Mary J1, Vinson Achenkunju, Menaka.K2, Sheik Haja Sherief2, T.Sivakumar3
1Pharm D. Interns, Department of Pharmacy Practice, Nandha College of Pharmacy, Perundurai main road, Erode, Tamil Nadu.
2Department of pharmacy practice, Nandha College of Pharmacy, Perundurai Main Road, Erode, Tamil Nadu.
3Principal, Nandha College of Pharmacy, Perundurai Main Road, Erode, Tamil Nadu.
Corresponding Author: Anjalimol P.T
ABSTRACT
Ceftriaxone is a third generation antibiotic from family of antibiotic from cephalosporin family of antibiotic having a broad spectrum activity. It is having a good activity against several gram negative organisms and anaerobes. Ceftriaxone used in the treatment of various gram negative infections such as respiratory tract infection, meningitis due to H. influenzae, Neisseria meningitis and S.pneumoniae and to treat gonorrhoea due to Neisseria gonorrhoea. Ceftriaxone therapy produces a potentially unusual life threatening hypersensitivity reactions. Whenever the patient is exposed to ceftriaxone produce IgE antibodies fix to mast cells then again reexposure to same drug antigen antibody reaction occurs on the mast cell surface then release of inflammatory mediators like histamine, 5 Histamine, Prostaglandins, Leukotrienes, Platelet Activating Factor these mediators cause urticaria, bronchospasm, hypotension, angioedema and anaphylactic shock. Management of hypersensitivity reaction includes Inj. Adrenaline 0.3,0.5mlIM, Inj Hydrocortisone-100-200mg IV, Inj Pheniramine 45 mg IV. Here we report 57 year female presented with the hypersensitivity reactions with ceftriaxone therapy.
Key words: Antibiotic, Adverse drug reactions, Ceftriaxone, hypersensitivity reactions.
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