Case Report
Year: 2019 | Month: November | Volume: 6 | Issue: 11 | Pages: 535-537
A Case Study on Guillain-Barre Syndrome with Peripheral Sensorimotor Neuropathy
Sneha Sebastian1, Sherine Justin1, Athira Thomson1, Sheik Hajasherief2
1Pharm D Interns, Department of Pharmacy Practice, Nandha College of Pharmacy, Perundurai Main Road, Erode, Tamil Nadu.
2Department of Pharmacy Practice, Nandha College of Pharmacy, Perundurai Main Road, Erode, Tamil Nadu.
Corresponding Author: Sneha Sebastian
ABSTRACT
Guillain-Barre Syndrome (GBS) can be described as the collection of clinical syndromes that includes acute inflammatory polyradiculoneuropathy with diminished reflexes and resultant weakness. A 25 year old male patient suddenly started a feeling of numbness of bilateral hands and sole followed by sudden onset of weakness of bilateral lower limb with difficulty in arising from floor and slowness of walking. On subsequent days the weakness was progressed to both lower and upper extremities and on clinical examination it was found that, distal sensory loss was present, bilateral hip of right was greater(grade 2) than left hip (grade 3).Muscle stretch reflex were absent. On neurological examination, the patient was alert, oriented and intact speech and memory, pupils equally react and cranial nerve was intact. All the laboratory parameters were normal but an elevated protein level of 2.05g/L with increased IgG fraction(25%). Nerve conduction study(NCS) were performed and all 4 limbs showed demyelinating motor sensory polyradiculoneuropathy. Sensory nerve action potentials(SNAP) amplitudes and sensory nerve conduction velocity(SNCV) of both upper and lower limb extremities revealed borderline prolonged distal latencies. Evoked amplitude of compound muscle action potentials (CMAPs) were of reduced amplitude and temporally dispersed reduced conduction velocity, prolonged or absent F-waves reflect proximal spinal roots and distal motor terminals. The patient received a 5-day course of IV immunoglobulins and underwent physiotherapy, speech and language therapy. GBS dependent upon early diagnosis and intervention may be important in the long term prognosis. Medical care for GBS patient is considered crucial for health care team.
Key words: Guillain-Barre Syndrome, Nerve Conduction Study, SNAP, SNCV, CMAP
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