Original Research Article
Year: 2019 | Month: December | Volume: 6 | Issue: 12 | Pages: 464-470
Dysregulation of H2S Level in Plasma and Alteration of Biochemical Parameters in Preeclampsia: A Hospital Based Study
Probir Kumar Roy1, Sanchayan Sinha1, Sukla Nath2, Soma Gupta3
1Junior Resident, 2Assistant Professor, 3Professor & Head,
Department of Biochemistry, NRS Medical College, Kolkata, West Bengal, India
Corresponding Author: Sukla Nath
ABSTRACT
Background: Preeclampsia is associated with high risk of maternal morbidity & adverse effect on fetal growth & development in our population. Though exact pathophysiology is unknown but there is compromised renal function causing alteration in various biochemical parameters which may cause detrimental effect on pregnancy outcome.
Aims & Objectives: to find out whether there is any significant difference in the level of H2S, LDH, and uric acid in patients with preeclampsia in comparison to normal pregnant women.
Materials & methods: 100 preeclampsia patients (cases) were compared with 100 age matched normotensive pregnant women (controls) for biochemical parameters in terms of plasma H2S, serum uric acid and LDH.
Result: The serum LDH concentrations in patients of preeclampsia is significantly (p =0.001) higher than the value in controls. The serum uric acid concentrations in patients of preeclampsia is also significantly (p =0.011) higher than the value in controls. Plasma H2S level is also significantly higher (p=0.008) in the patients of pre-eclampsia.
Discussion: The decreased level of H2S may result into endothelial dysfunction leading to hypoperfusion and placental insufficiency. As a result of reduced renal perfusion and glomerular filtration, Uric acid and LDH may get increased. No correlation of uric acid and LDH with H2S was observed which suggests the role of some other confounding factors in the pathogenesis of preeclampsia.
Key words: Preeclampsia, Proteinuria, Hypertension, Pregnancy, Eclampsia
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