Original Research Article
Year: 2019 | Month: March | Volume: 6 | Issue: 3 | Pages: 174-177
Measurement of Serum and Salivary TNF-α in Oral Lichen Planus Patients
Dr Sonia Gupta1, Dr. Nitin Ahuja2, Dr. Afreen Nadaf3
1Tutor, 3Lecturer,
Department of Oral Pathology and Microbiology, Govt. Dental College and Hospital Srinagar.
2Reader, Department of Oral Pathology and Microbiology, Institute of Dental Studies and Technologies, Kadrabad, Modinagar, (U.P.)
Corresponding Author: Dr Sonia Gupta
ABSTRACT
Background: Lichen planus is an inflammatory skin disorder with unclear etiology. TNF-α is a multifunctional cytokine which plays a major role in controlling cell proliferation, differentiation and apoptosis along with immunity and inflammation.
Aim: To determine the serum and salivary level of TNF-α in patients with oral lichen planus in
comparison with the healthy participants.
Materials and method: A cross-sectional study was conducted on 30 subjects, including normal oral mucosa (15 subjects) and oral lichen planus (15 subjects). The levels of serum and salivary TNF-α were evaluated using TNF-α ELISA test.
Results: The serum and salivary TNF-a level was significantly higher in lichen planus patients than in patients with normal oral mucosa.
Conclusion: The findings in this study suggest that TNF-α plays a major role in the pathogenesis of oral lichen planus.
Key words: Lichen planus, tumor necrosis factor- alpha, cytokine, saliva, serum
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