Original Research Article
Year: 2019 | Month: April | Volume: 6 | Issue: 4 | Pages: 161-169
An Observational Cross Sectional Study to Evaluate the Effect of Thyroid Hypo Function on Serum Creatinine and Serum Uric Acid Levels to Assess the Renal Status in an Urban Hypothyroid Female Population of Reproductive Age Group in Eastern India
Dr.Samarjit Koner1, Dr. Arunima Chaudhuri2
1Demonstrator Department of Biochemistry, College of Medicine and Sagore Dutta Hospital (Affiliated to West Bengal University of Health Sciences), Kamarhati, West Bengal, India.
2Associate Professor Department of Physiology, Rampurhat Government Medical College and Hospital (Affiliated to West Bengal University of Health Sciences), Rampurhat, West Bengal, India.
Corresponding Author: Dr. Arunima Chaudhuri
ABSTRACT
Background: Thyroid disorders are the most common worldwide and also in India. It is well documented that renal status such as elevated serum creatinine and serum uric acid levels are associated with hypothyroid state of the body.
Aims: To investigate the effect of hypothyroid state on Serum Creatinine and Serum Uric acid levels in an urban female hypothyroid population of reproductive age group in Eastern India.
Materials & methods: This present observational cross sectional study was conducted on 200 hypothyroid subjects in Burdwan Medical College for a period of 12 months after taking Institutional Ethical Clearance.100 controls were taken for the study. Serum TSH, FT4, Creatinine and Uric acid levels were estimated. The subjects were age matched. The computer software SPSS, version 16.0 was used for analyzing data.
Results: 200 hypothyroid subjects were enrolled for the study.48 hypothyroid patients were with increased Serum creatinine level (24%)and 43 with increased serum uric acid level(21.5%) Significant difference was observed between control and hypothyroid subjects for mean TSH (P<0.0001), mean FT4(P<0.0001),mean Creatinine (P<0.0001) and mean Uric acid(P<0.0001). No significant difference of age was found between two groups. Serum creatinine level was positively correlated with TSH (R=0.662, P<0.00001)) and negatively correlated with Sr. FT4(R= - 0.273,P=0.000092). Also we found a positive correlation between serum uric acid and TSH(R=0.669, P<0.00001), a negative correlation between serum uric acid and FT4(R= - 0.276,P=0.000076).
Conclusion: It is observed from our present study that serum creatinine and serum uric acid levels are significantly higher in Hypothyroid females in reproductive age group compared to control subjects. Therefore, patients with increased serum creatinine and serum uric acid levels should be investigated for hypothyroidism and it will help to avoid unnecessary treatment and concern related to such biochemical abnormalities with undetermined thyroid status of the subjects.
Key words: Hypothyroidism, Indian female population, FT4,TSH.Creatinine,Uric acid
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