Original Research Article
Year: 2019 | Month: April | Volume: 6 | Issue: 4 | Pages: 50-56
Alteration in Serum Creatine Phosphokinase in Hypothyroid Female Subjects of Reproductive Age Group in an Urban Population in Eastern India: A Cross Sectional Observational Study
Dr. Samarjit Koner1, Dr. Arunima Chaudhuri2
1Demonstrator Department of Biochemistry, College of Medicine and Sagore Dutta Hospital(Affiliated to West Bengal University of Health Sciences), Kamarhati, West Bengal, India.
2Associate Professor Department of Physiology, Rampurhat Government Medical College and Hospital (Affiliated to West Bengal University of Health Sciences), Rampurhat, West Bengal, India.
Corresponding Author: Dr. Arunima Chaudhuri
ABSTRACT
Background: Serum creatine phosphokinase (CPK) acts as important clinical parameter in muscle damage. Hypothyroid subjects may have elevated serum CPK level but correlation of the two is not well established till date.
Aims: To assess the significance of increased serum CPKlevel as biochemical tool in hypothyroidism in an urban young female population of reproductive age group in eastern India.
Materials & methods: This cross sectional study was conducted on 200 hypothyroid subjects in Burdwan Medical College in a period of 12 months after taking Institutional Ethical Clearance.100 subjects were enrolled in the study as control. Serum TSH, FT4 and CPKlevels were estimated.
The subjects were age matched. The computer software SPSS, version 16.0 was used for analyzing data.
Results: Among 200 hypothyroid subjects enrolled in the study, 50 hypothyroid patients had increased Serum CPKlevel (25%). Significant difference was observed between control and hypothyroid subjects for mean TSH(P<0.0001), mean FT4(P<0.0001) and mean CPK(P<0.0001).Serum CPK level was positively correlated with TSH levels (r=0.761, P<0.00001) and Serum CPK was negatively correlated with Sr. FT4(r= -0.328; P<0.00001).
Conclusions: It may be concluded from our study that Hypothyroid females in reproductive age group may have significant increase in serum CPK levels as compared to normal subjects and may be considered as important biochemical tool for the screening of muscle damage in hypothyroid individuals.
Key words: Creatine phosphokinase (CPK), Hypothyroidism, Indian female population.
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