Original Research Article
Year: 2019 | Month: June | Volume: 6 | Issue: 6 | Pages: 30-32
Association of Serum TNF-Alpha with Thyroid Parameters: A Hospital Based Study
Dr Piali Choudhury1, Dr. Sandip Chakraborty2, Dr Aihik Saha3, Sayan Mazumder4
1Demonstrator, 2Associate Professor, 3Postgraduate Trainee,
Department of Biochemistry, Nil Ratan Sircar Medical College, Kolkata, West Bengal
4M.Sc Biochemistry Student, Oriental Institute of Science and technology, West Bengal
Corresponding Author: Dr. Sandip Chakraborty
ABSTRACT
Auto-immune thyroiditis is one of the leading causes of thyroid dysfunction. However, the clinical presentation of the autoimmune thyroiditis shows a wide array of clinical presentation. The patients may remain clinically silent or even present with overt hypothyroidism. Studies suggest that autoimmune thyroiditis may result due to interplay of cytokines like C-reactive protein, interleukin-6 and tumor necrosis factor –alpha (TNF-α). Recent studies have seen an extensive role of inflammatory marker TNF-α in the regulation of thyroid transcription factor. This study was done to estimate the serum concentration of TNF-α in patients suffering from thyroid disorder and to see its variation from healthy controls. In this cross-sectional study serum TSH, Free T4 and TNF-α concentration was estimated in patients of thyroid dysfunction patients and compared with control group. Statistical analysis was performed using SPSS 21 and serum concentration of TNF-α was significantly higher in cases (p<0.05).
Key words: TNF-α, thyroid dysfunction, Auto-immune thyroiditis
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