Original Research Article
Year: 2019 | Month: July | Volume: 6 | Issue: 7 | Pages: 339-344
Study of Lipid Profile in Acute Viral Hepatitis
Dr. Mahesh Dave1, Dr. Shubham Kumar Sharma2, Dr. Tanay Surjan2
1Senior Professor and HOD, 2Senior Resident
Department of Medicine, R N T Medical College, Udaipur, Rajasthan, India
Corresponding Author: Dr. Shubham Kumar Sharma
ABSTRACT
Introduction: The viral hepatitis is an infectious disease caused by various hepatitis viruses which affect liver predominantly. Early prediction of impending complication is imperative to modify the cause and prognosis. Viral hepatitis may disturb metabolism of variable substances. This study ascertains the plasma lipid and lipoprotein pattern in subjects suffering from acute viral hepatitis and the change at six weeks follow up.
Aims and Objectives: (1) To study the changes in lipid and lipoprotein in acute viral hepatitis. (2)To study correlation between lipid and lipoprotein changes and severity of acute viral hepatitis. (3) To study the utility of lipid profile changes in prognosis of acute viral hepatitis.
Materials and Methods: This was hospital based prospective and follow up study, conducted on 50 patients who attended the Medicine department at R N T Medical college and MBGH, Udaipur.
Results: Out of 50 patients, majority were in between 21-40 years. 36(72%) were male. 29(58%) were positive for Hepatitis A, 2(4%) for Hepatitis B and 19(38%) for hepatitis E virus. Total cholesterol, triglyceride, LDL-C and VLDL-C were significantly raised, and HDL-C was significantly decreased at presentation as compared to follow up. There was no significant difference in lipid profile changes between viral hepatitis caused by different viruses. HDL-C was also significantly low in subjects who expired in comparison to who recovered.
Conclusion: The estimation of lipid levels is required for better assessment of hepatic function, prognostic assessment and management of viral hepatitis subjects. Increase in HDL-C during follow up in viral hepatitis appears to be a bad prognostic sign.
Key words: Viral Hepatitis, Lipid Profile, HDL-C.
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