Original Research Article
Year: 2019 | Month: July | Volume: 6 | Issue: 7 | Pages: 468-475
A Clinical Study of Febrile Thrombocytopenia with Special Reference to Complications and Seasonal Variation
Madhura Talkad Lakshmikumar1, Shruthi Bettegowda2, Smitha Joseph3
1Professor, 2Associate Professor,
Department of Medicine, Adichunchanagiri Institute of Medical Sciences, Balagangadharanatha Nagar, Nagamangala, Mandya -571448, India.
3Consultant, Holy cross hospital, Kollam, Kerala-691571, India.
Corresponding Author: Shruthi Bettegowda
ABSTRACT
Background: Infection is the commonest cause of thrombocytopenia. Commonly dengue, malaria, typhoid, septicaemia, and certain viral infections, present as fever with thrombocytopenia. The objective was to determine the aetiology for fever with thrombocytopenia and to study the presentation, laboratory profile, complications, prognosis and seasonal variation of thrombocytopenia.
Methods: This prospective observational clinical study was conducted between November 2015 – May 2017. One ninety patients aged > 18 years with fever and thrombocytopenia were included for this study. A detailed history, general and systemic examination and appropriate investigations were done and recorded.
Results: Out of 190 cases of fever with thrombocytopenia, 115 (60.5%) were males and 75 (39.5%) were females and the most common age group were between 20-30 years 50 (26.3%). The most common presentation was fever 190 (100%). Bleeding manifestations was present in 83(43.7%) cases. Common range of platelet count was in the range of 10000-20000 Lakhs/cumm 61 (32.1%). Infection was the commonest cause of thrombocytopenia and the commonest infection was dengue 131 (68.9%). One seventy nine (94.2%) cases had good recovery and 11(5.8%) patients have expired. Of those 11 mortality cases, all of them died due to septicemia. Among complications Coagulopathy was the most common with 21
(11.05%). Maximum numbers of cases of fever with thrombocytopenia are seen mainly during monsoon season.
Conclusion: Dengue being the commonest cause of febrile thrombocytopenia manifesting with seasonal variation commonly seen in monsoon season with cumulative effect of endemicity of disease in particular geographical region.
Key words: Dengue, Febrile thrombocytopenia, Multiorgan dysfunction, Septicemia.
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