Original Research Article
Year: 2019 | Month: August | Volume: 6 | Issue: 8 | Pages: 1-9
To Study the Association of Vitamin D and Inflammation in Prostate Cancer Patients of Northern India
Kanchan Taneja1, Seema Patel2, Aditi Sharma3, Pankaj Kamble4, B.C Kabi5
1Assistant Professor, Department of Biochemistry, Room no145, First Floor, Chacha Nehru Bal Chikitsalaya, New Delhi, India. 110031.
2Assistant Professor, Department of Biochemistry, ESIC Medical College, Faridabad, Haryana. India. 121012.
3Aditi Sharma, Senior Resident, Department of Biochemistry, V.M.M.C and Safdarjung Hospital,
New Delhi- 110029, India.
4Assistant Professor, Department of Biochemistry, S.M.B.T. Institute of Medical Sciences and Research Centre, Nashik, Maharashtra, India. 422403.
5Professor, Department of Biochemistry, V.M.M.C and Safdarjung Hospital New Delhi- 110029, India.
Corresponding Author: Seema Patel
ABSTRACT
Introduction: Prostate cancer is one of the important causes of morbidity and mortality in men worldwide. Inflammation plays an eminent role in cancer CRP is a well-known inflammatory marker and anti-inflammatory and anticancer effect of vitamin D has long been known. Hence, we sought to study the levels of vitamin D levels along with CRP levels in prostate cancer patients.
Materials and Methods: The study was conducted in Department of biochemistry in association with Department of urology, VMMC and SJH, New Delhi. The case control study included forty newly diagnosed cases of prostate cancer patients histologically confirmed by transrectal needle biopsy with elevated PSA level>4ng/ml and forty age matched healthy control. Vitamin D, CRP and PSA levels were estimated and its association seen.
Results: Vitamin D was significantly low and CRP significantly high in prostate cancer patients compared to control. Further the study also found a significant negative association between vitamin D and CRP.
Conclusion: A marked decrease in vitamin D associated with increase in CRP supports the inflammatory etiology of Prostate cancer. It has been known that vitamin D receptors and enzymes are also expressed in human prostate epithelial cells and vitamin D has potential immunomodulatory role. Vitamin D supplementation may prove to be beneficial in prostate cancer patients against the high economic costs of chemotherapy and morbidity of the patients.
Key words: Prostate cancer, CRP, Vitamin D, PSA, Inflammation
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