Original Research Article
Year: 2019 | Month: August | Volume: 6 | Issue: 8 | Pages: 203-208
Correlation of Ca15-3 and CEA in Different Molecular Subtypes of Metastatic Breast Cancer
Poonam Sinha1, Rekha Kumari2, Manish Kumar3, Ranjay Kumar Ranjan4, Uday Kumar5
1Junior Resident, Department of Biochemistry, IGIMS, Patna.
2Additional Professor &HOD, Department of Biochemistry, IGIMS , Patna.
3Assistant Professor, Department of Surgical Oncology, IGIMS, Patna.
4Junior Resident, Department of FMT, NMCH, Patna.
5Professor, Department of Biochemistry, PMCH, Patna.
Corresponding Author: Rekha Kumari
ABSTRACT
Introduction: Breast cancer is the most common cancer occurring in woman worldwide. Nearly 25% of all cancers is breast cancer with 1.67 million new cases diagnosed in 2012.In recent years, in patients of breast cancer, prognostic value of preoperative CEA and CA15-3 levels has gained much attention. Study has revealed that preoperative plasma level of CEA combined with CA15-3 may provide useful information for diagnosis and treatment of breast cancer.
Aims & objectives: To correlate CA 15-3 and CEA level with clinicopathological parameters for early diagnosis and prognosis of metastatic breast cancer.
Materials and Methods: This prospective study was done in department of biochemistry, IGIMS Patna.75 diagnosed metastatic breast cancer patients of age group 30-70 years were included in this study. Correlation of CA15-3 and CEA levels with clinicopathological parameters were analysed .
Results: In 75 patients of metastatic breast cancer, elevated CA 15-3 and CEA levels were seen in 44 (58.6%) and 26(34.7%) patients, respectively. Level of CA 15-3 and CEA were significantly associated with different molecular subtypes (p=0.025 and p=0.043, respectively). CA15.3 level was more elevated in Luminal A, Luminal B, and HER2 positive cases whereas CEA level was more elevated in HER2 positive cases. Elevation of CA 15-3 was significantly more common in multiple site metastasis of breast cancer compared with a single site metastasis (p<0.0001). However, elevated CEA levels was not significant between patients with a single and those with multiple site metastasis.
Conclusions: Elevation of CA 15-3 and CEA levels were found to be significantly associated with different molecular subtypes of metastatic breast cancer and CA15-3 level was also significantly associated with multiple site metastasis of malignant breast cancer.
Key words: metastatic breast cancer, cancer antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), clinicopathological parameters.
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