Original Research Article
Year: 2019 | Month: September | Volume: 6 | Issue: 9 | Pages: 123-127
A Prospective Study of Lipid Profile Changes In Patients on Anti-Epileptic Drug Therapy
Dr. Shubham Sareen1, Dr. R. K. Vyas2, Dr. Yogita Soni3, Dr. Anita Verma4, Dr. Rupali Vyas5, Dr. Geeta5, Miss Prerna5
1Resident Doctor, 2Sr.Professor, 3Professor, 4Asso.Professor, 5M.Sc.Student,
Dept. of Biochemistry, S. P. Medical College, Bikaner, Rajasthan, India
Corresponding Author: Dr. Shubham Sareen
ABSTRACT
Introduction: Epilepsy is one of the commonest neurological disorders often requiring long term treatment with anti-epileptic drugs (AED’s). Many biochemical side-effects occur in patients who take AED’s for chronic diseases. Alterations in Serum Lipid Profile due to AED’s can have serious implications for the patients in future in the form of an adverse cardiovascular or cerebrovascular event. Increase in Serum cholesterol, especially LDL Cholesterol accelerates atherosclerotic changes in the form of plaque formation in arteries. Since, most epileptic patients are of younger age group ,an early and rapid start of atherosclerosis in them will have an adverse cardiovascular impact in later age.
Materials and Methods: A prospective study was done on 30 newly diagnosed epilepsy patients. Blood samples were collected before starting anti-epileptic drugs and repeated after 8 months of drug treatment. Samples were also taken from 20 healthy age and sex matched controls. All samples were analysed for Serum Lipid profile on Beckman-Coulter fully automatic analyser.
Results: Total Cholesterol and LDL cholesterol were significantly higher (p<0.05) after 8 months of AED’s use. Triglyceride levels though raised, were not statistically significant.(p>0.05)
Conclusion: Adverse impact on blood lipids occurs due to long term use of AED’s which necessitates corrective action to halt adverse vascular events in future.
Key words: Anti-epileptic drugs (AED’s), Epilepsy, lipid profile, LDL, atherosclerosis
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