Review Article
Year: 2020 | Month: October | Volume: 7 | Issue: 10 | Pages: 172-184
Biochemistry of Non Infectious Hepatitis - A Review
Lamiya, A1,2, Bello, B1, Adda, D. K2
1Department of Biochemistry, Modibbo Adama University of Technology Yola, Adamawa State, Nigeria
2Department of Research, Center for Initiative and Development Taraba, Taraba State, Nigeria
Corresponding Author: Lamiya, A.
ABSTRACT
Hepatitis is a medical condition defined by inflammation of the liver and characterized by the presence of inflammatory cells in the liver parenchyma. There are several types of hepatitis including viral, autoimmune, fatty liver, alcoholic, drug-induced and toxin-induced hepatitis. Many causes and mechanism of pathogenesis of some of these types of hepatitis particularly the non-infectious/non-viral hepatitis still remain to be understood despite the economic and health burden it places in the health, economic and scientific realm. However, research is a loose ended and continuous process hence proper understanding of present findings will provide a background for further studies in a bid to unravel some of the mysteries in non-infectious hepatitis hence a more efficient and effective approach of treatment/management of the ailment. This article attempts to discuss the causes of non-infectious forms of hepatitis which can be a sequel of metabolism disorder/syndrome, nutrition, toxification due to xenobiotics and or genetic disorder / predisposition. Possible mechanisms of pathogenesis that were captured include induction of oxidative stress, organelles dysfunction, apoptosis, necrosis, genetic modulation, electrolyte imbalance, uncoupling of mitochondrial electron transport chain among others.
Keywords: hepatitis; non-infectious/non-viral hepatitis; mechanism; pathogenesis; toxification; xenobiotics
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