Original Research Article
Year: 2020 | Month: October | Volume: 7 | Issue: 10 | Pages: 311-317
Study of the Levels of Trace Elements (Cu, Mg, Zn) in Psoriasis Patients: A Case Control Study
Sara Mohammed1, Faizan i Asrar Nazki2, Safa Mohammed3Syyeda Anees4, Bader-UZ-Zaman5
1MD Biochemistry, Deccan College of Medical Sciences, Santosh Nagar, Hyderabad.
2MD Biochemistry, Demonstrator, Department of Biochemistry, Government Medical College Srinagar J and K.
3Postgraduate Student, Department of Biochemistry, Gandhi Medical College Secunderabad.
4 Professor, Department of Biochemistry, DCMS Hyderabad (TS)
5Professor, Department of Biochemistry, DCMS Hyderabad (TS)
Corresponding Author: Faizan i Asrar Nazki
ABSTRACT
Aim: To study levels of trace elements (Cu, Mg, Zn) in psoriasis patients
Material and Methods: A total of 50 cases diagnosed for psoriasis were undertaken during the study period in the test group. 50 healthy individuals with no skin disease were taken as control group. The cases were taken from the department of Dermatology. Blood samples were collected and analyzed in the department of Biochemistry, Owaisi Hospital and Research Centre (OHRC). Serum FRAP Assay, Copper, Magnesium and Zinc were estimated in both the groups.
Results: Serum FRAP Assay were lowered in psoriasis patients than controls indicating that total antioxidant levels are decreased in psoriasis than controls. Decreased total antioxidant levels may be due to depressed state of antioxidant system or due to oxidative stress in these patients.Serum copper levels were increased in psoriasis patients than controls. Serum zinc levels in psoriasis patients were significantly low in psoriasis patients when compared to controls. Serum Magnesium levels in psoriasis were significantly decreased in psoriasis patients than controls.
Conclusion: This study highlights the possible role of trace metals copper and zinc in the etio-pathogenesis of psoriasis and also provides a proposed interplay of factors involved in the pathogenesis of psoriasis.
Keywords: Psoriasis, trace elements, FRAP
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