Review Article
Year: 2020 | Month: October | Volume: 7 | Issue: 10 | Pages: 472-483
A Review on Hydrotropic Solubilization: A Novel Approach for Solubility Enhancement of Poorly Water Soluble Drugs
Praveena. A. T1, Arun. J. L2
1M.Pharm, Department of Pharmaceutics, The Dale View College of Pharmacy and Research Centre, Punalal, Thiruvananthapuram, Kerala.
2Associate Professor, Department of Pharmaceutics, The Dale View College of Pharmacy and Research Centre, Punalal, Thiruvananthapuram, Kerala.
Corresponding Author: Praveena. A. T
ABSTRACT
The field of drug discovery and development plays a major role in the world and serves mankind. The great challenge in screening studies as well as formulation of new chemical entities is the solubilization of poorly soluble drugs. Inorder to improve the solubility of poorly water soluble drugs, a number of methodologies can be adapted. Hydrotropes are a unique molecular phenomenon, that possess the ability to increase the solubility of sparingly soluble and poorly soluble drugs in water. It can be defined as adding a second solute to the primary one. Several advantages that makes the solubilization technique superior are high selectivity, non-inflammability, environmentally friendly, easy availability and cost effectiveness. This technique may have some disadvantages like cost, toxicity and environmental hazards. This can be overcome by using less costly hydrotropic agents. Nowadays hydrotropic agents are used to develop dosage forms in various forms such as solid dispersion, mouth dissolving tablets, injections. These are for improving the therapeutic effectiveness and bioavailability of poorly water soluble drugs.
Keywords: Solubility, Hydrotropy, Solubility enhancement, Hydrotropic agent, Poorly water soluble drugs, Solid dispersions, Membrane permeability, Self aggregation, Permeation enhancers, Mixed hydrotropy.
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