Original Research Article
Year: 2020 | Month: October | Volume: 7 | Issue: 10 | Pages: 551-556
Evaluation of Extra Pulmonary Tuberculosis in a Tertiary Care Centre in Kerala, South India, Utilising GeneXpert
Beena Philomina Jose1, Aishwarya Praveen Kumar2, Anuja Mohan3
1Professor, Department of Microbiology, Government Medical College Kozhikode.
2Assistant Professor, Department of Microbiology, Government Medical College Kozhikode.
3Senior Resident, Department of Microbiology, Government Medical College Kozhikode.
Corresponding Author: Aishwarya Praveen Kumar
ABSTRACT
Even as pulmonary tuberculosis presents significant diagnostic challenges, diagnosis of extrapulmonary tuberculosis can be even more challenging. 1145 extrapulmonary samples were tested over a period of 2years, out of which Mycobacterium tuberculosis was detected in 144samples (12.6%). Samples included pleural fluid, lymph node aspirate & biopsy, cerebrospinal fluid and other sterile body fluids, synovial biopsy, ileocaecal biopsy and pus aspirates from abscess. Rifampicin resistance was detected in 6 samples (5 lymph node aspirates and 1 pleural fluid). All 6 were first line treatment failure cases who were started on second line antituberculous treatment. Xpert® MTB/RIF assay was found to be highly useful for diagnosis of lymph node tuberculosis and least for diagnosing tuberculous effusions.
Keywords: Tuberculosis, Extrapulmonary tuberculosis, GeneXpert, Rifampicin resistance, CBNAAT.
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