Original Research Article
Year: 2020 | Month: October | Volume: 7 | Issue: 10 | Pages: 572-578
Comparison of Serum Arginine, Nitric Oxide Reactive Species in Hypertensive Patients with and Without Microalbuminuria
Nilachal Behera1, Upendra Kumar Das2, Roma Rattan3, M. K. Mandal4
1PG student, 2Associate Professor, 3Associate Professor, 4Professor & HOD,
Dept. of Biochemistry, SCB Medical College, Cuttack
Corresponding Author: Upendra Kumar Das
ABSTRACT
Aim of the study: Hypertension (HTN) is associated with deranged endothelial dysfunction. The level of serum Nitric oxide affects the endothelial function & is synthesized from Arginine. Hypertension leads to clinical proteinuria & a significant reduction in renal function. Microalbuminuria indicates the renal status, The objective of this study is to find out the difference between serum Arginine, Nitric oxide in patients with hypertension with microalbuminuria & without microalbuminuria and the relation between NO & microalbuminuria.
Material & Method: The study included 62 patients with hypertension without microalbuminuria, 60 patients with hypertension with microalbuminuria and 60 healthy controls were included in our study. The levels of all biochemical parameters , arginine, NO, urinary albumin were estimated and compared .
Result: Serum Arginine, NO levels show significant decrease in both hypertensive patients without & with microalbuminuria when compared with control. There is a significant increase in urinary albumin level in hypertensive patients with microalbuminuria. There exist a negative correlation between NO & urinary albumin in hypertension with microalbuminuria.
Conclusion: As L-Arginine is only source of NO, so therapeutic role of Arginine may be contemplated.
Keywords: Hypertension, NO, Microalbuminuria.
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