Original Research Article
Year: 2020 | Month: November | Volume: 7 | Issue: 11 | Pages: 252-257
Study on Association of Glycation Gap in Diabetes Mellitus with Renal Complication
Sthitapragyan Mishra1, Upendra Kumar Das2, Roma Rattan3, Manmath Kumar Mandal4 , Anoj Kumar Baliarsingh5
1Tutor, 2Associate Professor, 3Associate Professor, 4Professor & HOD, Department of Biochemistry, 5Ex- Prof & HOD, Endocrinology, SCB Medical College, Cuttack
Corresponding Author: Upendra Kumar Das
ABSTRACT
Aim of the study: Type 2 Diabetes Mellitus is a chronic disease characterized by insulin resistance, impaired insulin secretion and increased glucose production. Due to increased blood glucose level, the blood proteins are non-enzymatically conjugated with glucose. HbA1c & fructosamine are formed, they reflect the mean blood sugar. Glycation Gap is calculated as the difference between HbA1c and HbA1c value predicted from fructosamine value. Glycation Gap is related to onset of renal complication. The objective of the study is to find out the association of Glycation Gap with renal complication.
Material & Method: The study included 59 diabetic patients without renal complication, 60 diabetic patients with renal complication and 64 healthy controls. The different biochemical parameters, urinary albumin excretion rate (UAER) were estimated and compared.
Result: HbA1c, fructosamine, Glycation Gap are increased significantly in diabetes without and with renal complication. There is significant increase in urinary albumin excretion in diabetes mellitus with complication in compare to diabetes without complication. A positive correlation is found between Glycation Gap & urinary albumin excretion rate. There is significant relation between Glycation Gap & occurrence of renal complication in diabetes.
Conclusion: Glycation Gap can reflect presence of disease and diabetic complication.
Keywords: fructosamine, Glycation Gap, HbA1c, UAER
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