Case Report
Year: 2020 | Month: November | Volume: 7 | Issue: 11 | Pages: 342-345
“Stage B2 Thymoma Presenting with Myasthenia Gravis” Successfully Treated with Multimodality Treatment: A Case Report from Tertiary Cancer Centre in North India
Sharma Jyoti1, Sharma Damini2
1MD Radiotherapy Tertiary Cancer Centre, IGMC Shimla, (H.P), India
22nd year Junior Resident (MD Radiotherapy) MBBS, Tertiary Cancer Centre IGMC Shimla (H.P), India
Corresponding Author: Sharma Jyoti
ABSTRACT
Thymomas are rare tumors and account for less than 1% of the human cancers. As these tumors are exceedingly rare and having unpredictable natural history multimodality Rx consisting of surgery as mainstay of treatment, adjuvant radiotherapy for local control and chemotherapy is often practiced. Incidence for patients associated with myasthenia Gravis is high in 4th decade whereas for patients without myasthenia gravis, the peak age is in the 7th decade or later.
Case Report: We present a case of WHO stage B2 Thymoma in a 35-year-old male patient who reported in neurology department in a higher centre with complaints of drooping of eyelids, difficulty in chewing food and generalized weakness. A diagnosis of Myasthenia Gravis was made treatment was started for the same. His CECT Thorax revealed well defined oval homogenously enhancing mass on right side s/o thymoma. Metastatic workup revealed no sign of metastasis.
Results: At our institute he underwent total thymectomy which revealed Minimally invasive thymoma (B2) with invasion into capsule and peri thymic adipose tissue. Patient was treated with adjuvant radiotherapy 56Gy/28# to the tumor bed and four rounds of chemotherapy based on CAP. Response was assessed with the help of CECT Thorax which revealed no e/o residual disease.
Conclusion: Type B2 Thymoma usually present with either encapsulated or partially circumscribed tumors and have tendency to invade mediastinal fat/other organs. However, there are chances of recurrence of 5-9%. Our patient successfully completed multimodality treatment and is disease free since past 1 year.
Keywords: B2 Thymoma, lymphoepithelial, mediastinal neoplasms, WHO Classification.
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