Research Paper
Year: 2020 | Month: November | Volume: 7 | Issue: 11 | Pages: 596-601
Determining the Mechanism of Female Hypogonadism in Diabetic Population in Eastern India: An Original Article
Muhammad Fauzie Sahil, Ratih Puty Hariandy, Sarah Dina
Department of Obstetrics and Gynaecology, Medical School, University of Sumatera Utara, H. Adam Malik General Hospital, Medan
Corresponding Author: Muhammad Fauzie Sahil
ABSTRACT
Introduction: Endometrial carcinoma is a primary malignant tumour in the endometrial epithelium and the second gynecologic malignancy after cervical carcinoma in the world. The incidence of endometrial carcinoma increased as the increasing of life expectancy and obesity epidemic. Surgery is the definitive therapy, but some patients with surgical pathology risk are necessary to perform adjuvant therapy. Assessment of hormone receptor, in this case, is progesterone receptor, could be applicable in evaluating risk factors patients whereby it will affect the prognosis.
Method: This is a cross-sectional study. Sixty-five sample consisting of block paraffin tissue of the endometrium from endometrial carcinoma cancer type I who underwent surgery in Adam Malik General Hospital Medan. Immunohistochemistry assay to determine progesterone receptor expression and statistical analysis performed to assess the relationship between progesterone receptor expression with cell differentiation and the stage of endometrial carcinoma-Chi-square analysis with confidence of interval 95%, p<0.05 is significant.
Result: The result of the study, of Sixty-five endometrial carcinoma patients, found the majority of age is > 50 years (67.7%), with BMI overweight (44.6%), well-differentiated cell (44.6%) and stage III (41.5%). Positive progesterone receptor expression found in 30 patients (46.2%) and negative in 35 patients (53.8%). In this study found there is a significant relationship between cell differentiation and the stage of endometrial carcinoma (p<0.05). The decreasing of progesterone receptor expression means the poorer of cell differentiation (r = -0.659) and increasing the stage of endometrial carcinoma (r = -0.428).
Conclusion: There is a significant relationship between progesterone receptor expression with cell differentiation and the stage of endometrial carcinoma (p<0.05). The decreasing of progesterone receptor expression means more inadequate cell differentiation (r = -0.659) and increasing the stage of endometrial carcinoma (r = -0.428).
Keywords: Endometrial Carcinoma, Progesterone Receptor, Cell Differentiation, Stage.
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