Original Research Article
Year: 2020 | Month: December | Volume: 7 | Issue: 12 | Pages: 108-111
Comparative Observational Study of Serum Lipid Abnormalities in Type 2 Diabetes Mellitus Patients with or Without Diabetic Nephropathy
Amar Kant Amar
Department of Endocrinology, Indira Gandhi Institute of Medical Sciences. Patna, Bihar.
ABSTRACT
Objective: The main objective of the study was comparatively evaluation of serum lipid abnormalities in type 2 diabetes mellitus patients with or without diabetic nephropathy.
Methods & materials: This is an observational study to explore the lipid abnormalities in diabetic patients with or without diabetic nephropathy. After taking patients consent demographic details like weight, height, age, weight were documented in a predesigned proforma and serological test was performed to identify , glycemic parameters like fasting blood glucose (FBG) , post prandial blood glucose (PPBG), glycated haemoglobin and serum lipid parameters like total cholesterol(TC), serum triglycerides (TG), Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL).
Results: It was observed that both with and without nephropathy group had almost similar age group which was 52.7±9.79 and 53.4±9.35 years respectively. Between two groups there was no statistically significant difference (p value=0.823) as per age is concern. There were significant statistical differences in glycemic parameters and serial lipid parameters in-between the two groups. With nephropathy group, 70% of T2DM patients and without nephropathy group 44% of T2DM patients had dyslipidemia. Atherogenic dyslipidemia was observed 7% in diabetes with nephropathy group and 11% in without nephropathy group. In nephropathy group there were a higher percentage of subjects with dyslipidemia (p value=0.02).
Conclusion: In the management of diabetes an important therapeutic target identified as dyslipidemia. Abnormal lipoprotein metabolism accelerates diabetic nephropathy which causes cardiovascular disease as well as the progression of diabetic nephropathy.
Keywords: serum lipid abnormalities, type 2 diabetes mellitus, diabetic nephropathy.
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