Original Research Article
Year: 2020 | Month: January | Volume: 7 | Issue: 1 | Pages: 61-64
A Study Comparing Histopathological Grade of Breast Carcinoma with Her2/Neu Status in a Tertiary Care Hospital
Reeta Dhar1, Omar Bali2, P. Patro3, Ameya Weling4, Talat Noor Shaikh2, Jyotsna Sahai5, Priyanka Gaikwad5, Anshika Rai5
1Professor (Department of pathology, MGM hospital Navi, Mumbai),
2Third year post-graduate students (MGM hospital Navi, Mumbai),
3Associate Professor (MGM hospital Navi, Mumbai),
4 M.B.B.S Student (M.G.M Medical College)
5Second Year Post-Graduate Students.
Corresponding Author: Omar Bali
ABSTRACT
Introduction: Breast cancer is a leading cause of concern in today’s medical care and newer diagnostic tools like immunohistochemistry have been frequently implemented in diagnostic efforts in addition to the existing histopathological findings. It is important to see how these two diagnostic modalities show up as a whole and in relation to each other. Through this study, we make an effort to accomplish just the same.
Aims and Objectives: To look at the observations and comparative findings of histopathological grade and immunohistochemical (HER2/neu) markers and find any correlation that may be of help to future studies.
Materials and Methods: A sample of 50 patients with Invasive breast ca were observed and their histopathological grades (Nottingham scoring) were sent along with immunohistochemistry done (HER2/neu). Results and noted and tallied with each other.
Results: It was observed that there were maximum cases of grade 2 followed by 3 and then 1. Also that there were more HER2/neu negative cases than positive. Also that the frequency of HER2/neu positivity was more in grade 1 yet quantity of cases of HER2/neu positivity turned out to be more in grade 2.
Conclusion: It would be very helpful to keep a close eye on even lower grades of Breast carcinoma as they would have a high chance of HER2/neu positivity and thus poor prognosis.
Keywords: Breast; Carcinoma; HER2/neu; Histopathological; Grading; Immunohistochemistry
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