Original Research Article
Year: 2020 | Month: January | Volume: 7 | Issue: 1 | Pages: 439-442
Visual Evoked Potential in Children with Thalassemia
Banita Negi1, Praveen Bhardwaj2, Sudhir Sharma3, Minoo Sharma4, Pratima Thakur5
1Senior Resident, Department of Pediatrics, Dr. RPGMC, Tanda, Kangra,( H.P)
2Associate Professor, Department of Pediatrics, IGMC Shimla (H.P)
3Associate Professor, Department of Neurology, IGMC Shimla (H.P)
4Assistant professor, Department of Physiology, IGMC Shimla (H.P)
5Senior Resident, Department of Pediatrics, SLBSGMCH Nerchowk(H.P)
Corresponding Author: Banita Negi
ABSTRACT
Background and Aim: Beta thalassemia has a spectrum of varied manifestations and complications. Survival is associated with various multisystem complications primarily caused by chronic anemia, iron overload, adverse effects of chelation, and transfusion-associated infections. Thus, a disease that starts merely as hemolytic anemia attains the dimension of a chronic disease with multisystem involvement. Neurological involvement is initially subclinical and can only be detected during neurophysiological or neuroimaging evaluation. Abnormal findings in the visual evoked potential recordings are mainly attributed to deferoxamine neurotoxicity. Aim was to study visual evoked potential in thalassemia children and effect of iron overload on visual evoked potential.
Methods: 30 children with thalassemia on regular transfusion and iron chelation therapy and 30 healthy age and sex matched controls were subjected to visual evoked potential. Statistical analysis used: means of quantitative variables were calculated in two groups and compared with student t- test. A p-value of <0.05 was taken as significant.
Results: On comparing the results between cases and controls, there was no significant difference in p100 wave latency of both eyes (p>0.05). On comparing two groups of cases (group I with serum ferritin level<1000ng/ml and group II with serum ferritin level>1000ng/ml) serum ferritin level was significantly associated with greater p100 latency in both right and left eye in group II of cases.
Conclusions: We concluded that in children with thalassemia on regular transfusion and Iron chelation regime, visual evoked potential is normal in comparison to normal control but with progressive increase in serum ferritin level, the latency is increased and is statistically significant.
Keywords: Deferasirox, Ferritin, Visual Evoked Potential, Thalassemia
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