Original Research Article
Year: 2020 | Month: January | Volume: 7 | Issue: 1 | Pages: 506-510
Correlation of Urinary Protein Creatinine Ratio with 24-Hour Urinary Protein in Indian Patients
Kamakshi Narula1, Sanjeev K. Verma2, Shahbaj Ahmad3
1Senior Resident, 2Professor, 3DNB (Nephrology), Assistant professor,
Department of General Medicine. Himalayan Institute of Medical Sciences, SRHU Dehradun 248 016.
Corresponding Author: Shahbaj Ahmad
ABSTRACT
Background: 24-hour urinary protein (24-UP) is the gold standard for the assessment of proteinuria, but urine collection is tedious and prone to error. So spot urinary protein creatinine ratio (UPCR) is used as a surrogate for 24-UP. There are only a few studies which have validated the correlation between UPCR with 24-UP in Indian population.
Aims: To assess the correlation between UPCR with 24-UP in Indian patients.
Settings and Design: Cross sectional study in a tertiary teaching health centre.
Methods: The study was of one-year duration, which included adult patients with dip stick positive proteinuria. The patients with uncontrolled hypertension or diabetes, febrile illness, raised serum creatinine, pregnancy or during the menstrual period were excluded. All the patients collected 24-hour urine samples on a normal diet and routine daily activity. Following day the patient submitted the cane of 24-hour urine & a separate container with freshly voided urine.
Statistical analysis used: Mean, standard deviation & Pearson’s correlation coefficient.
Results: Out of 112 patients, only 100 samples were included for final analysis. The mean age of the finally included 100 patients was 53.3 years, of which 68% were male. The mean 24-UP & UPCR were 3200.58 ± 2969.66 & 3.12, respectively. Pearson's correlation coefficient between UPCR & 24-UP was 0.78. The relationship was stronger at a lower level of proteinuria.
Conclusions: UPCR shows a good correlation with 24-UP in the Indian patients, and can be used as a surrogate for timed urine collection for proteinuria.
Keywords: 24-hour urinary protein, Dipstick, Indian patients, Proteinuria, UPCR, Urinary creatinine, Urinary protein.
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