Original Research Article
Year: 2020 | Month: March | Volume: 7 | Issue: 3 | Pages: 145-150
Toxicological Profiling of a Siddha Formulation Ghendhiyathi Uppu in Experimental Rodents
Thilagavathi.R1, Kavitha.T2, Esaivani.S2, Susila.R2
1Research Officer (Siddha), Siddha Clinical Research Unit, Bengaluru
2Research Officer (Siddha), Siddha Central Research Institute, Arumbakkam, Chennai
Corresponding Author: Thilagavathi.R
ABSTRACT
Ghendhiyathi Uppu(GU) is a Siddha formulation indicated in literature for Pleurisy. This study was aimed to evaluate the Acute and Chronic oral toxicity study of Ghendhiyathi Uppu(GU) in albino rats to evaluate the traditional claims for the safety of the test drug. It was observed that the formulation was found to be non-toxic at dosage of 1600mg/100gm body weight of the animal in albino rats and so it can be classified under category-4 of globally harmonized system of classification and labelling of chemicals in Acute toxicity study and the drug produces mild histopathological changes during long term administration at the dose of 200mg/100gm of body weight, but not in the lower dose of 100mg/100gm of body weight of the animal. The biochemical and haematological parameters were analysed and the Histopathological study was performed after 90 days repeated oral toxicity. Through this study the Siddha formulation Ghendhiyathi Uppu(GU) can be evidently accepted to be nontoxic to the humanity at the lower dose of 100mg/100gm of the body weight.
Keywords: Ghendhiyathi Uppu(GU), Siddha, Acute toxicity, Chronic toxicity, Traditional medicine.
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