Original Research Article
Year: 2020 | Month: March | Volume: 7 | Issue: 3 | Pages: 352-358
Association of Microalbuminuria with Ischemic Stroke among Patients Admitted In a Tertiary Health Care Hospital in North India
Varsha Kachroo1, Parvaiz Dar1, Vijay Kundal2
1Resident, Dept. of Medicine, Government Medical College, Jammu
2Professor, Dept. of Medicine, Government Medical College, Jammu
Corresponding Author: Varsha Kachroo
ABSTRACT
Background: Microalbuminuria defined as urinary albumin excretion of 30-300 mg/24hrs is considered a marker of vascular endothelial damage and thereby of atherosclerosis; which is cornerstone of the pathogenesis of ischemic stroke. The present study was done to highlight the association of microalbuminuria with ischemic stroke.
Methods: This was an institution based study conducted over a period of one year at GMC Jammu. It consisted of 100 ischemic stroke patients fulfilling inclusion criteria. The severity of stroke was assessed by NIHSS score and urine for albumin was estimated by chemiluminescence technique.
Results: Out of 100 patients, 47%(47out of 100) had microalbuminuria and 51% didn’t have. Mean NIHSS score of patients with microalbuminuria was 21.8 ± 9.42. Mean albumin excretion amongst mild stroke patients was 36 ± 2.77 and in severe stroke was 147.38 ± 26.3. As the albumin excretion increased, the severity of stroke in terms of NIHSS also increased. Thus, a graded correlation existed between severity and amount of albumin excretion among microalbuminurics. This correlation was highly significant with correlation coefficient of 0.904 and p value of <0.0001. No graded correlation existed between severity of stroke in terms of NIHSS and albumin excretion below the range of microalbuminuria.
Conclusion: Microalbuminuria was found in significant number of ischemic stroke patients and was independently associated with adverse outcomes in terms of severity of stroke.
Keywords: Ischemic Stroke, Microalbuminuria, NIHSS score
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