Original Research Article
Year: 2020 | Month: April | Volume: 7 | Issue: 4 | Pages: 286-294
Study of the Clinical Profile of Rapidly Progressive Glomerulonephritis
Areca Wangnoo1, Pankaj Banotra1, S K Bali2
1Resident, Department of General Medicine, Government Medical College, Jammu
2Professor, Department of General Medicine, Government Medical College, Jammu
Corresponding Author: Areca Wangnoo
ABSTRACT
RPGN is a type of nephritic syndrome, accompanied by extensive glomerular crescent formation that, if untreated, progresses to end-stage renal disease over weeks to months. Our study aims to identify factors affecting the treatment outcome in RPGN.
Materials and Methods: A hospital based cross sectional study conducted in the Department of Nephrology at Government Medical College, Jammu for a period of one year after obtaining ethical clearance. Adults with rapidly progressive glomerulonephritis on the basis of renal biopsy were included. Routine clinical. biochemical parameters and biopsy findings were analyzed. Primary outcome identified the remission of the patient with 24-hour urine protein <500 mg/day and serum creatinine <1.4 mg/dl. Quantitative variables were compared using Mann-Whitney Test and qualitative variables were correlated using Chi-Square test/Fisher’s exact test. A p value of <0.05 was considered statistically significant.
Results: In our study, about two-third of patients (63.64%) had showed no response. About one-fourth (25.45%) of patients showed partial remission and 10.91% had complete remission. Age, gender, duration of symptoms prior to diagnosis, oliguria, hematuria, hemoptysis, quantity of proteinuria were not correlated with the primary outcomes. Significant correlation was observed with variables like entry serum creatinine, entry eGFR and need of RRT on admission. More than half (90%) of our patients had secondary complications like anemia followed by infections (67%).
Conclusion: RPGN is an important cause of renal failure. Most of the patients present late to hospital. Serum creatinine and requirement of dialysis at presentation are important predictors for outcome in RPGN. Thus, to improve outcome, an early referral to nephrologist for early diagnosis and treatment is stressed.
Keywords: glomerulonephritis, RPGN, nephritic syndrome, renal biopsy
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