Review Article
Year: 2020 | Month: July | Volume: 7 | Issue: 7 | Pages: 285-292
Effect of High Levels of Testosterone on Cardiovascular Risk in Polycystic Ovary Syndrome (PCOS)
Suku Sneha
Fortis Hospital, Sector 62, Noida, Uttar Pradesh – 201301
ABSTRACT
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by oligo ovulation, hyperandrogenism and the presence of polycystic ovaries. PCOS is closely related to the hyperandrogensim (HA). Postmenopausal hyperandrogenism is a condition of relative or absolute androgen excess originating from either the adrenals and/or the ovaries. Clinical manifestations of HA include hirsutism, acne, androgenic alopecia and virilisation. In PCOS women, HA has been associated with metabolic disturbances that increase the risk for cardiovascular disease (CVD). Many clinical studies have underlined the relationship between PCOS and cardiovascular risk is due to a lipid or glucose altered metabolism, hypertension, systemic inflammatory condition and vascular injuries. In this review article, we mainly focussed on PCOS related cardiovascular disease due to increased levels of testosterone. Management of hyperandrogenism along with life-style intervention has beneficial effects on cardiovascular risk factors in PCOS. We determined the etiology of relative and absolute androgen excess in postmenopausal women and this review provides extensive overview on the development of cardiovascular risk factors in PCOS females due to increased levels of testosterone.
Keywords: Polycystic ovary syndrome, oligo ovulation, hyperandrogenism, hirsutism, alopecia, virilisation, hypertension, vascular injuries and cardiovascular events
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