Original Research Article
Year: 2020 | Month: August | Volume: 7 | Issue: 8 | Pages: 429-433
Bacteriological Profile & Antibiogram of Urinary Tract Infections in a Tertiary Care Hospital
Ramalakshmi Koripella1, T. Kanakadurgamba2, K. Vasanthi3, Appa Rao Peddapalli4
1Associate Professor, 2Assistant Professor, 3Msc PG, 4Professor and HOD,
Department of Microbiology, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India.
Corresponding Author: T. Kanakadurgamba
ABSTRACT
Background: UTI is the second most common clinical indication for empirical antimicrobial treatment in primary and secondary care setting. ESBL producing bacteria are typically associated with MDR. Hence, the present study was done to isolate and identify the pathogenic agents of UTI, their antibiotic susceptibility pattern and detection of ESBLs and MRSA of the isolated organisms in a tertiary care hospital.
Materials & Methods: A total of 175 urine samples of patients suffering from UTI were included in the study. Isolation and identification of organisms was done as per standard protocols in the laboratory. Antibiotic sensitivity test was done by Kirby-Bauer disc diffusion method and interpretation done as per CLSI guidelines.
Results: In the present study, out of 175 samples, 48 (27.4%) were culture positive and 127 (72.6%) sterile. Out of the 48 positive cultures, E.Coli were isolated predominantly (54.1%) followed by Klebsiella species (27%), Pseudomonas aeruginosa (8.3%), Staphylococcus aureus (6.2%) and Enterococci (4.1%). Most of the gram positive cocci were sensitive to vancomycin (94%) followed by amikacin and linezolid (90% each) and imipenem(88%) while gram negative bacilli were sensitive to colistin(96%), amikacin(92.5%) and imipenem(90%). MRSA were 33.3% and ESBLs 24.4%.
Conclusion: Resistance to beta lactam antibiotics has increased significantly in the last two decades and current updated knowledge of the susceptibility pattern of bacteria is vital for the appropriate assortment and utilization of antimicrobial drugs and for prescribing suitable guidelines.
Keywords: UTI, Antibiotic sensitivity, E.coli, Klebsiella, ESBLs
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