Case Report
Year: 2020 | Month: September | Volume: 7 | Issue: 9 | Pages: 322-325
Anti-Nmda Receptor Autoimmune Encephalitis- A Case Report
Syam Prakash K R1*, Maheshwari.V 1, Ajeena Anto1, Tasneem Abdul Gafoor1, Sulfath T.S2*
1*PharmD Interns, Department of Pharmacy Practice, Nandha College of Pharmacy, Erode, Tamil Nadu, India
2*Nephrology Clinical Pharmacist, Department of Clinical Pharmacy, IQRAA International Hospital and Research Centre, Calicut, India
Corresponding Author: Syam Prakash K R
ABSTRACT
One of the most popular autoimmune encephalitis is the Anti-N-methyl D-aspartate (NMDA) receptor (anti-NMDAR) encephalitis. N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is a potentially fatal autoimmune syndrome that generates antibodies against NMDAR causing severe dysregulation of neurotransmission. Auto immune encephalitis is a growing category of clinical syndromes that may occur at any age. Such conditions are associated with antibodies to proteins from the surface of neuronal cells and synaptic receptors involved in synaptic transmission, plasticity, or neuronal excitation. A 38 year old female patient was admitted in ICU presented with seizure on 2 days (1st episode and next day 2nd episode) and altered sensorium. The patient has severe, prolonged and potentially fatal pathological bilateral ovarian dermoid . Patients most often present with a constellation of neuropsychiatric signs and symptoms, including memory loss, hallucinations, and decreased level of consciousness. This patient has also the same neuropsychiatric signs and symptoms. This condition is lethal if left untreated. Immunomodulation, high dose of steroids and surgical resection of the culprit malignancy often results in the rapid resolution of symptoms with an excellent prognosis.
Keywords: Anti-N-methyl D- aspartate, Autoimmune encephalitis, Neurotransmission, Seizure, Altered sensorium
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