Review Article
Year: 2020 | Month: September | Volume: 7 | Issue: 9 | Pages: 425-429
Is There a Linking Cable between COVID-19 and Human Brain Diseases?
Vanita Jamba1, Prabhudas Patel2, Nikhil Modi3, Trupti Trivedi4
1Junior Research Fellow, Clinical Carcinogenesis Lab, Cancer Biology Department, Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, India
2Professor & Head, Cancer Biology Department, Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, India
3MS- Neurosurgeon, Neuro-Oncology Department, Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, India
4Senior Scientific Officer & Head, Clinical Carcinogenesis Lab, Cancer Biology Department, Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, India
Corresponding Author: Trupti Trivedi
ABSTRACT
The novel Severe Acute Respiratory Syndrome (SARS-CoV-2) was first identified in Wuhan, China- 2019, which spreaded its extensions in whole world and made the world a sulking graveyard. There are seven different types of coronavirus, among which SARS-CoV has evolved itself in the nature and has become a life-threatening infection to mankind. This review is focused for the identification of linkage between the Novel Coronavirus(COVID-19) and human brain diseases. The common symptoms which are reported till now in COVID 19 are: fever, cough, fatigue, anosmia and ageusia. Whereas, the patients with more fatal infection are reported to suffer fromacute cerebrovascular diseases, impaired consciousness, skeletal muscle injury, arterial and venous thrombosis and acute necrotizing encephalopathy as severe symptoms. Its exact path for neural manifestation is still not established. However, it was expected to be attached with Angiotensin Converting Enzyme-2 (ACE-2), which interacts with capillary endothelium, thus breaking the Blood-Brain Barrier (BBB) and causing shortness of breath due to scarcity of oxygen. To confirm the exact source and path of neurological connection with COVID-19, there is need of autopsies which will give a light in this darkening situation of the world.
Keywords: COVID-19, Brain, Blood-Brain Barrier (BBB), Acute Necrotizing Encephalopathy (ANE).
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