Original Research Article
Year: 2021 | Month: November | Volume: 8 | Issue: 11 | Pages: 286-292
DOI: https://doi.org/10.52403/ijrr.20211137
Comparison of Intravenous Dexmedetomidine versus Labetalol for Their Effectiveness in Suppression of Haemodynamic Response during Extubation
Parth M. Shah1, Divya Kheskani2
1Associate Professor, Dr. M.K. Shah Medical College, Hospital & Research Centre, Shyanmal, Satellite, Ahmedabad - 380015, Gujarat.
2Assistant Professor, GCS Medical College, Hospital & Research Centre, Shyanmal, Satellite, Ahmedabad - 380015, Gujarat.
Corresponding Author: Divya Kheskani
ABSTRACT
Background: Tracheal extubation causes autonomic nervous system disturbances which causes tachycardia, hypertension which are harmful in susceptible patients.so we conducted a study between iv Dexmedetomidine and iv Labetalol to assess their effectiveness in decreasing haemodynamic disturbances during extubation.
Materials and Methods:we included 100 participants of age of 18-55 yrs with ASA grading I & II and divided them into 2 groups. Group D was given injection Dexmedetomidine 0.6mcg/kg iv and Group L was given injection Labetalol 0.25mg/kg body weight. We recorded Heart rate, systolic and diastolic blood pressure at baseline, 2,5,8 minutes post drug injection, at extubation and 1,3,5,8,10 and 15 minutes after extubation.
Results: Group D had better decreased heart rate, systolic and diastolic blood pressure at the time of extubation, and also 15 minutes post extubation in comparison to Group L.
Conclusion: Injection Dexmedetomidine 0.6µg/kg has showed a better attenuating effect on sympathoadrenal system during extubation than injection Labetalol 0.25mg/kg
Keywords: Dexmedetomidine, labetalol, extubation,hemodynamics.
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