Original Research Article
Year: 2021 | Month: December | Volume: 8 | Issue: 12 | Pages: 378-383
DOI: https://doi.org/10.52403/ijrr.20211246
Relationship between Neutrophil Lymphocyte Ratio (NLR) and Anxiety Levels among COVID-19 Patients at H. Adam Malik General Hospital Medan
Habibie Hasyim Lubis1, Wika Hanida Lubis2, Tambar Kembaren3
1Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara
2Division of Psychosomatic, Department of Internal Medicine, Faculty of Medicine Universitas Sumatera Utara
3Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Sumatera Utara
Corresponding Author: Habibie Hasyim Lubis
ABSTRACT
Background: COVID-19 caused great anxiety and stress in patients, especially those treated in isolation wards. SARS-CoV-2 infected respiratory tract and caused acute respiratory syndrome with the consequent release of pro-inflammatory cytokines, such as IL-1β and IL-6, resulting in a "cytokine storm". These cytokines were also elevated in psychiatric disorders such as depression, anxiety, schizophrenia, and post-traumatic stress disorder. Therefore, this study aimed to determine the relationship between NLR and anxiety levels in COVID-19 patients at RSUP. H Adam Malik.
Methods: This was an analytic observational study using cross-sectional design. This study was conducted from February to August 2021 on confirmed COVID-19 patients being treated at H. Adam Malik Hospital. The patient's anxiety scale was measured using the Beck Anxiety Inventory (BAI) questionnaire. The NLR value were taken from the results of a blood test performed when patient was first admitted to the isolation room. The data were coded, tabulated, and analyzed using SPSS 23.00 software. The magnitude of the desired deviation (α) was 0.05, with p value of <0.05.
Results: The median NLR ratio among 50 confirmed COVID-19 patients in each group respectively was 2.18, 5.03, 3.57 and 8.37. The median NLR ratio increased accordingly to the level of anxiety in COVID-19 patients, with p-value of <0.05 (p = 0.034).
Conclusion: NLR ratio was significantly related to anxiety level among COVID-19 patients.
Keywords: NLR, Anxiety Level, COVID-19, Neutrophil Lymphocyte Ratio.
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