Original Research Article
Year: 2021 | Month: December | Volume: 8 | Issue: 12 | Pages: 650-656
DOI: https://doi.org/10.52403/ijrr.20211280
The Relationship of Ghrelin Level with Levels of Cluster of Differentiation 4 (CD4) in Human Immunodeficiency Virus (HIV) Patients Receiving Antiretroviral (ARV) Therapy
Ibrahim Tanaka1, Dharma Lindarto2, Santi Syafril2
1,2Department of Internal Medicine, Faculty of Medicine, University Sumatera Utara, H. Adam Malik General Hospital Medan
Corresponding Author: Ibrahim Tanaka
ABSTRACT
Background: Ghrelin is primarily involved in the secretion of growth hormone (GH), glucose and lipid metabolism. HIV infection is thought to affect ghrelin levels in HIV patients, especially in patients with lipodystrophy. However, this effect is still unclear because many studies have obtained different results about low or high levels of ghrelin in people with HIV. Suppression of HIV replication with ART rapidly increases CD4 cell count. However, data on the effect of antiretroviral therapy on ghrelin levels is still scant.
Aim: To examine the relationship between ghrelin levels and CD4 levels in HIV patients receiving ARV therapy.
Method: This research is an observational analysis study, with cross-sectional design, implemented start from April 2020 in Tropical Diseases & Infection Polyclinic, H. Adam Malik Hospital. Blood samples were taken and examined at the Clinical Pathology Laboratory. Primary and secondary data collection from interviews and direct observation. Data will be analyzed with Pearson correlation test if normally distributed or Spearman's test if the data is not normally distributed using SPSS software.
Results: A total of 43 the sample consists of 38 patient who received the AFC, 3 patients received Duviral + Efafirens, 1 patient received Tenofovir + Hiviral + Aluvia dan 1 patient received Tenofovir + Hiviral + Neviral. Demographic characteristics based on th highest ages group are 21-30 years and 31-40 years, each of which is 17 people. The correlation of ghrelin level with levels of CD4 on the HIV patient taking ARV shows a significance value of 0.943, it can be concluded that there was no significant relationship between Ghrelin levels and CD4.
Conclusion: There was no correlation between ghrelin levels with CD4 levels on HIV patient receiving ARV therapy.
Keywords: Ghrelin, HIV, CD4, Antiretrovirals.
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