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Review Article

Year: 2021 | Month: February | Volume: 8 | Issue: 2 | Pages: 277-283

DOI: https://doi.org/10.52403/ijrr.20210239

C-Reactive Protein and its Association with Periodontitis and Atherosclerosis: a Review

Kamalkishor Mankar¹, Pranjali Bawankar², Dhawal Mody³

¹Associate Professor, Department of Periodontics and Implantology, VSPM Dental College & Research Centre, Nagpur
²Senior Lecturer, Department of Periodontics and Implantology, VSPM Dental College & Research Centre, Nagpur
³Reader, Department of Periodontics and Implantology, VSPM Dental College & Research Centre, Nagpur

Corresponding Author: Pranjali Bawankar

ABSTRACT

Periodontal disease is a chronic inflammatory processes resulting from interaction of specific gram negative bacterial species with the host defense in disease susceptible individuals. The host responds to the microbial challenge, with increased levels of pro and anti-inflammatory cytokines like IL-1, IL-10, IL-8, IL-6, TNF-α etc. These mediators endorse activation of the acute phase reactants resulting in elevated serum levels of CRP, α1-acid glycoprotein, ceruloplasmin, serum amyloid A. CRP thus produced due to local periodontal infection has negative after effects on systemic health. High serum CRP concentrations can be of high risk for future cardiovascular disease and events. Pre assessment of serum C reactive protein in chronic periodontitis can predict the risk of developing cardiovascular disease in future and thereby can help in diagnosis at earlier stages and can aid in providing screening services and advice to seek immediate dental care. This review highlights the bidirectional associations between the cardiovascular disease marker CRP and periodontitis.

Keywords: Periodontitis, Periodontal Therapy, atherosclerosis, C -reactive protein.

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