Original Research Article
Year: 2021 | Month: March | Volume: 8 | Issue: 3 | Pages: 168-174
Efficacy of Hydroxychloroquine in Uncontrolled Type 2 Diabetes Mellitus Subjects with Adhesive Capsulitis
MD. Ekram1, Shaibal Guha2, Naveen Kumar3
1Associate Professor, Department of Orthopedics, Madhubani Medical College & Hospital, Bihar;
2Diabetologist, Positive Health Centre, Patna;
3Diabetologist, Global Diabetes Care & Research Centre, Darbhanga, Bihar
Corresponding Author: MD. Ekram
ABSTRACT
Aims: The aim of this observational study is to evaluate efficacy of hydroxychloroquine in uncontrolled type 2 diabetes mellitus subjects with frozen shoulder.
Materials and methods: This was an open label, multicentre, prospective observational trial. Total 134 consecutive patients of Type 2 diabetes mellitus with adhesive capsulitis of shoulder joint were included in this study, who were inadequately control (HbA1c ≥7 to ≤10%) on two oral antidiabetic drugs. All the subjects were put on HYQ 400 mg OD and followed up for 24 weeks with clinical and biochemical parameters monitoring.
Results: All the 134 subjects on two oral agents (Metformin 1 gm and Glimepiride 4 mg). The mean age in males and females were 57 and 82 years respectively. The average body weight was 82.3 kg and BMI was 29 kg/m2. The average duration of diabetes was 5.8 years. The mean baseline HbA1c was 8.9 %, which reduced to 7.5 % at the end of 24 weeks. The mean baseline FPG was 164 mg/dl, which was reduced to 124 mg/dl while the mean baseline PPG was 223 mg/dl which reduced to 164 mg/dl at the end of 24 weeks. Serum creatinine remained unchanged. The mean baseline hs-CRP was 5.87 mg/dl, which reduced to 1.12 mg/dl at the end of 24 weeks. There was a clinically significant change in body weight.
Conclusion: Hydroxychloroquine 400 mg once a day is an effective add-on for getting dual benefits of glycemic control and resolution of shoulder adhesive capsulitis, when appropriately used in poorly controlled type 2 diabetes mellitus patients on dual oral agents with adhesive capsulitis.
Keywords: Hydroxychloroquine, Type 2 Diabetes, adhesive capsulitis, HbA1c.
[PDF Full Text]