Research Paper
Year: 2021 | Month: March | Volume: 8 | Issue: 3 | Pages: 410-414
Correlation of HbA1C and TNF-α Levels in Diabetic Patients with Pulmonary Tuberculosis after Intensive Phase of Tuberculosis Treatment
Wika Lydia1, Aron Pase2, Melati Silvanni Nasution2, Santi Syafril2, Dharma Lindarto2
1Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara
2Division of Endocrinology Metabolic and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara
Corresponding Author: Wika Lydia
ABSTRACT
Introduction: In 2013, there are 8.5 million people with diabetes mellitus (DM) in Indonesia, placing the country as the 7th highest number of DM cases. The poor controlled of DM could lead to several manifestations, including tuberculosis (TB) infections. In TB patients, Tumor Necrosis Factor-α (TNF-α) helps controlling the infection, but it may cause insulin resistance. Until date, there is no study investigating the correlation of these two laboratory parameters. We aimed to perform the correlation of HbA1C and TNF-α level in DM with TB after intensive phase of TB treatment.
Methods: The study was conducted from August to September 2019 in USU Hospital, Madani Medan Hospital, and Teladan Health Center. Patients diagnosed as DM type 2 with current insulin treatment were recruited. TB cases were determined by microscopic tests and X-ray. Blood specimens were drawn before and after intensive phase of treatment.
Results: We included 25 subjects in total, 19 (76%) were male. The laboratory data of subjects showed high level of HbA1C (9.40 ± 0.96 g%). Mean TNF-α of subjects was 503.87 ± 77.02 pg/mL. The data analysis showed significant decrease of TNF-α and HbA1C levels before and after intensive phase of antituberculosis treatment (p = 0,000; p = 0.000), positive correlation of TNF-α and HbA1C levels after intensive phase of antituberculosis treatment (r = 0.791; r = 0.827; p = 0.000).
Conclusion: There was significant decreased level of HbA1C before and after 2 months TB treatment. HbA1C level did not have significant correlation to TNF-α level.
Keywords: diabetes, tuberculosis, HbA1C, TNF-α, cytokine.
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