Original Research Article
Year: 2021 | Month: March | Volume: 8 | Issue: 3 | Pages: 415-429
A Study on Trends and Usage Pattern of Antibiotics among In-Patients in a Tertiary Care Hospital
Abhishek Pradhan1, Fatima Ridha Safar2, Akhil Raj2, Abhilash C2, Architha Aithal2, A.R Shabarayya3
1Asst. Professor, Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka, India – 574143.
2Student, Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka, India – 574143.
3Professor & Head, Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka, India – 574143
Corresponding Author: Fatima Ridha Safar
ABSTRACT
Antibiotics have effectively prolonged life expectancy and ‘antibiotics’ revolution has turned the entire landscape of infectious disease by making them curable. Currently, Antibiotics are assumed to be the most commonly prescribed drugs in hospitals, worldwide. But, excessive and inappropriate use of antibiotics renders increased drug resistance, and hence, need for a study regarding sensitivity and resistance pattern of antibiotics for proposal or implementation of rational therapy guidelines. This study will also provide microbiological information to clinicians to pick the most effective treatment options, positively influencing patient outcomes. A prospective observational study was conducted in a total of 220 patients at Srinivas Institute of Medical Science and Research Centre, Mangalore, for a period of six months. In-Patients of either gender who are 18 years old or above, in Respiratory and Nephrology department prescribed with antibiotics were included in the study. Patients under other departments and the ones who are not prescribed with antibiotics and pediatric patients were excluded from the study. Data were collected using a validated data collection form. Data were analyzed using MS Excel 2016. From a total of 220 patients involved in the study, majority were females and young adults in both the departments. The most prescribed antibiotic was found to be Piperacillin - Tazobactam of doses 4.5g and 2.25g. Gram negative organisms isolated were 82.30%, and out of these Klebsiella species being the most frequent. These organisms showed high rates of sensitivity towards Meropenem and Gentamicin. Sensitivity of antibiotics towards species was found to be dwindling and it is an unpleasant warning of emergence of resistance. It can be anticipated in the developing society and routine culturing and sensitivity testing can be performed to detect the emergence of resistance.
Keywords: Infection, Antibiotic, Organisms, Resistance, Sensitivity.
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