Original Research Article
Year: 2021 | Month: May | Volume: 8 | Issue: 5 | Pages: 138-142
DOI: https://doi.org/10.52403/ijrr.20210520
Correlation of Oxidative Stress to Severity of Acute Organophosphorus Poisoning
Somia Bashira, Firdous Khanb, Maria Bashirc
aDemonstrator, Department of Forensic Medicine and Toxicology, SKIMS Medical College, Bemina J&K
bLecturer, Department of Forensic Medicine and Toxicology, Govt Medical College, Srinagar, J&K
cPost Graduate Doctor, Department of Physiology, Govt Medical College, Srinagar, J&K
Corresponding Author: Somia Bashir
ABSTRACT
Organophosphorus compounds may induce oxidative stress leading to generation of free radicals and alterations in antioxidant and scavengers of oxygen free radicals. The present study included one hundred and sixteen patients who had organophosphorus (OP) poisoning of 3-5 hours duration from the time of consuming the poison. The study focused to elucidate the role of free radicals in organophosphorus toxicity by estimation of various oxidative stress markers. The results of the study suggest significant alteration of these oxidative stress markers which in turn suggests significant free radical generation due to OP poisoning. This may be due to overuse failure of the antioxidant defence system secondary to excessive reactive oxygen species production.
The study also indicated that the incidence of poisoning was more common among males. Overall, the study found that accidental poisoning was far less than suicidal cases with homicidal cases being the rarest. Most of the patients belonged to rural areas.
Keywords: organophosphorus, oxidative stress.
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