Original Research Article
Year: 2021 | Month: July | Volume: 8 | Issue: 7 | Pages: 359-364
DOI: https://doi.org/10.52403/ijrr.20210750
Urinary Neutrophil Gelatinase-Associated Lipocalin in Type 1 and Type 2 Hepatorenal Syndrome and Its Correlation with Kidney Function
Lider Olmen Panggabean1, Gontar Alamsyah Siregar2, Dharma Lindarto3, Masrul Lubis2
1Department of Internal Medicine, Faculty of Medicine, Sumatera Utara University, Medan
2Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Sumatera Utara University, Medan
3Division of Metabolic and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Sumatera Utara University, Medan
Corresponding Author: Gontar Alamsyah Siregar
ABSTRACT
Objective: To determine the difference in urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) levels in type 1 and type 2 Hepatorenal Syndrome (HRS) and determine the correlation between urinary NGAL and kidney function and the degree of liver disease severity in HRS patients.
Methods: A total of 26 patients consisting of 13 patients in each group, both in type 1 and type 2 HRS at Adam Malik Hospital, Medan City, Indonesia. Urine samples were taken for NGAL examination using the ELISA method. A blood sample is used to assess kidney function. Liver disease severity was measured using the Child-pugh score. Data were analyzed using statistical t-test independent and Pearson correlation test. A p value less than 0.05 was applied to each statistical test as significant.
Result: Total subjects consisted of 18 men and 8 women, with a mean age 57.5±8.91 years old. Hepatitis B virus was the most common etiology of liver cirrhosis in this study (53.8%) and the most degree of liver disease severity was Child-pugh C (65.4%). Urinary NGAL levels in type 1 HRS is significantly higher than type 2 (155.71±43.04 vs 105.85±32.32 ng/ml, p = 0.003). There was a positive correlation between uNGAL and serum creatinine (r = 0.488, P = 0.006). There was a positive correlation between uNGAL and Child-pugh score (r = 0.466, P = 0.008).
Conclusion: Urinary NGAL level in type 1 HRS is higher than type 2, there is a positive correlation between uNGAL and serum creatinine and Child-pugh score in HRS patients.
Keywords: Hepatorenal syndrome, urinary NGAL, Liver cirrhosis, kidney function.
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