Original Research Article
Year: 2021 | Month: August | Volume: 8 | Issue: 8 | Pages: 171-175
DOI: https://doi.org/10.52403/ijrr.20210823
Association between VEGF -2578 C> A Polymorphism with VEGF Serum Levels in Gastritis with Helicobacter Pylori
Tara Rizvira Monica*, Gontar Alamsyah Siregar**, Taufik Sungkar**, Dharma Lindarto***
*Department of Internal Medicine, Faculty of Medicine, Sumatera Utara University, Medan
**Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Sumatera Utara University, Medan
*** Division of Metabolic and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Sumatera Utara University, Medan
Corresponding Author: Gontar Alamsyah Siregar
ABSTRACT
Mucosal damage in people with gastritis causes the production of VEGF. VEGF is a neoangiogenesis function to repair damaged tissue. Excess production can cause cancer risk. VEGF genotype polymorphisms are thought to affect the production of serum VEGF levels. The aim of this study was to determine the relationship between VEGF - 2578 C> A polymorphism and serum VEGF levels in H. pylori gastritis.
Method: cross-sectional study was conducted at H. Adam Malik General Hospital and Network Hospital with 100 samples. Endoscopic examination was performed to assess the gastric mucosa and a tissue biopsy was performed. The urea breath test (UBT) test and the Campylobacter like organism (CLO) test to determine H. pylori infection. VEGF - 2578 C> A was checked by Polymerase Chain Reaction (PCR). The data will be analyzed by univariate and bivariate.
Result: One hundred people with gastritis, of which 59 people were infected with H. pylori. In this study, H. pylori infection did not have a significant relationship with VEGF levels. VEGF - 2578 C> A polymorphisms also had no relationship to serum VEGF levels.
Conclusion: There is no correlation between VEGF - 2578 C> A polymorphism with VEGF serum levels (p> 0.05).
Keywords: VEGF polymorphisms, VEGF - 2578 CA, H. pylori, Gastritis.
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