Original Research Article
Year: 2021 | Month: August | Volume: 8 | Issue: 8 | Pages: 13-18
DOI: https://doi.org/10.52403/ijrr.20210803
Association between VEGF-2578 C>A Polymorphism with Gastric Premalignant Lesion in Gastritis with Helicobacter
Mario Eka Paskah Sinulingga1, Gontar Alamsyah Siregar2, Ilhamd2, Dharma Lindarto3
1Department of Internal Medicine, Faculty of Medicine, Sumatera Utara University, Medan
2Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Sumatera Utara University, Medan
3Division of Metabolic and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Sumatera Utara University, Medan
Corresponding Author: Gontar Alamsyah Siregar
ABSTRACT
Introduction: Gastric cancer is one of the most common causes of cancer-related deaths worldwide. Many epidemiological studies have shown several risk factors associated with the development of gastric cancer, including gastritis. The most common cause of gastritis is H. pylori infection. In the H.pylori-infected mucosa, there was a significant increase in VEGF levels. Several SNPs are thought to be involved in the etiology of malignancy, one of which is the VEGF-2578C>A polymorphism.
Methods: A cross sectional study was conducted in Medan with 59 H. Pylori gastritis patients. Endoscopic examination was performed to assess the gastric mucosa. H.pylori status was determined by examination of Urea breath Test (UBT) and Campylobacter Like Organism (CLO) test followed by histopathological studies evaluating the presence of changes to pre-malignant lesions such as chronic atrophic gastritis, intestinal metaplasia, intestinal dysplasia. Genotype analysis was carried out using Polymerase Chain Reaction (RT-PCR). Data analysis was carried out by univariate and bivariate
Result: Of the 59 patients with H. pylori gastritis, 35.8% of patients showed premalignant lesions. The majority of premalignant lesions had a CC genotype (37.9%, n = 11), but there was no significant relationship between the VEGF-2578 C>A polymorphism and the incidence of gastric premalignant lesions.
Conclusion: Based on this study, the VEGF -2578C>A polymorphism was not associated with gastric premalignant lesions in H. pylori gastritis patients..
Keywords: Polymorphism VEGF, VEGF -2578C>A, Premalignant lesions, H. Pylori.
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