Review Article
Year: 2022 | Month: November | Volume: 9 | Issue: 11 | Pages: 7-20
DOI: https://doi.org/10.52403/ijrr.20221102
COVID-19 Infection and Acute Kidney Injury in Paediatric Population: A Systematic Review and Meta-Analysis
Snehashis Koley1, Ambar Bose1, Sudeshna Mallik2, Prantiki Halder2, Mandira Mukherjee1
11Department of Biochemistry and Medical Biotechnology, School of Tropical Medicine, Kolkata, West Bengal, India
2Department of Tropical Medicine, School of Tropical Medicine, Kolkata, West Bengal, India
Corresponding Author: Mandira Mukherjee
ABSTRACT
Background: Acute Kidney Injury (AKI) posed a dreaded health complication in COVID-19 infection in paediatrics. In this review we systematically documented evidence on AKI incidence and associated death in COVID-19 infection among paediatric populations to aid healthcare workers towards appropriate clinical management.
Methods: Documentation on AKI incidence and associated death in COVID-19 infection worldwide in paediatrics in PubMed and medRxiv databases during December, 2019-June19, 2021 was included in this study. Guidelines laid by Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) were followed which facilitated clarity and transparency in the reporting.
Result: 23 out of 1976 total articles were eligible with mean age of 8.6 years. Database of Abstract of Reviews of Effects (DARE) tool was used for quality assessment. Studies on AKI incidence (19), mortality (19) and AKI related mortality (10) respectively were included for meta-analysis. An estimated AKI incidence of 28.8%with overall death of 2.3% and AKI related death of 5.2% were reported. Overall pooled AKI incidence in the paediatric population was statistically significant.
Conclusion: Therefore, aggressive investigation of COVID-19 infection associated with AKI in paediatrics posed a necessity for efficient health-care management.
Keywords: Acute kidney injury; Box plot; COVID-19; Forest plot; Meta-analysis
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